The role of thiol-disulfide and ischemia-modified albumin levels in the diagnosis of childhood appendicitis

Aim: The accurate diagnosis of acute appendicitis can be achieved by a combination evaluation clinical symptoms, physical examination findings and history taking, but is still challenging for the clinician. Some biochemical markers have been evaluated purpose increasing diagnostic accuracy rate appendicitis. In this study, our aim to evaluate value thiol-disulfide levels IMA, in pediatric patients with suspected 
 Materials And Methods:
 children (1-17 years age) who were admitted clinic between March 2017 September evaluated. A total 238 are enrolled study; 119 operated did not constituted control group. Serum native thiol (-SH), (SH + SS), dynamic disulfide (SS), (SS)/total SS) ratio, albumin, ischemic modified albumin (IMA) WBC obtained compared within groups. Results: mean age was 10.9 (±3.7, 3-17 years) 9.1 1-17 operation groups, respectively. SH, SH+SS, SS SS/SH+SS ratio significantly lower IMA higher group than Among patients, non-perforated perforated significant decrease serum observed postoperative 1st day when preoperative values.
 Conclusion:
 Measuring thiol/disulfide homeostasis may increase evaluating However, it appears that these evaluations fail distinguish appendicitis, thus further studies necessary.